By Serena McNiff
Whereas it isn’t clear exactly how SARS-CoV-2 causes clots, a brand new research means that the quantity of a specific protein — known as issue V — in a affected person’s blood could have one thing to do with it.
In March, researchers at Massachusetts Common Hospital obtained a blood pattern from a affected person with extreme COVID-19 and seen one thing uncommon. The affected person’s blood had considerably above-normal ranges of issue V.
Researchers then studied greater than 100 sufferers handled within the intensive care unit for COVID-19.
Excessive ranges of issue V have been discovered throughout the group, and almost half of the sufferers had above-normal ranges. When researchers in contrast the samples to historic information, greater than 1 in 10 sufferers had larger issue V ranges than had been seen earlier than on the hospital.
“Except for COVID-19, I’ve by no means seen anything trigger markedly elevated issue V, and I have been doing this for 25 years,” research co-author Dr. Elizabeth Van Cott stated in a hospital information launch. She is a pathology investigator at Mass Common and a pathology professor at Harvard Medical Faculty.
The research discovered that sufferers with elevated issue V have been extra prone to have blood clots within the lungs, known as pulmonary embolism, and deep vein thrombosis (DVT), or clots within the veins.
Of sufferers with excessive ranges of issue V, one-third had both DVT or a pulmonary embolism, in contrast with 13% of sufferers with decrease ranges.
Whereas sufferers with excessive issue V ranges have been at higher threat for clotting issues, sufferers with decrease issue V ranges had a better threat of loss of life, researchers discovered.
A lower in issue V ranges may point out sufferers are progressing to a severe and sometimes deadly situation wherein clotting processes develop into overactive, Van Cott and colleagues stated.
They stated the findings may assist determine which sufferers are at elevated threat of blood clots and loss of life.
The findings have been just lately printed on-line within the American Journal of Hematology.